Subscribe To Our Feed To Lose Weight

Subscribe here, only if you want to receive all new posts into your mail inbox ;)

Do Weight Loss Pills Work? 5 Drugs Compared by FDA

Med Coolman | Wednesday, June 29, 2016 | | | |

Weight Loss Pills

In an analysis that included nearly 30,000 overweight or obese adults, compared with placebo, orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were each associated with achieving at least 5 percent weight loss at 52 weeks, and phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss, according to a study appearing in the June 14 issue of JAMA.



Approximately 1.9 billion adults are overweight and 600 million are obese worldwide. Identifying effective long-term treatment strategies for overweight and obesity is of paramount importance. The U.S. Food and Drug Administration (FDA) has approved 5 weight loss drugs (orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide) for long-term use in obese (body mass index [BMI] ? 30) or overweight (BMI ? 27) individuals with at least 1 weight-associated condition (type 2 diabetes, hypertension, hyperlipidemia). Data on the comparative effectiveness of these drugs are limited.


Siddharth Singh, M.D., M.S., of the University of California, San Diego, La Jolla, and colleagues conducted a systematic review and meta-analysis of randomized clinical trials that included overweight and obese adults treated with FDA-approved long-term weight loss agents for at least 1 year compared with another active agent or placebo. Twenty-eight randomized clinical trials with 29,018 patients (median age, 46 years; 74 percent women; median baseline body weight, 222 lbs.; median baseline BMI, 36.1) were included.


Also read: Taking Folic Acid During Pregnancy May Reduce Childhood Obesity Risk

The researchers found that a median 23 percent of placebo participants had at least 5 percent weight loss vs 75 percent of participants taking phentermine-topiramate, 63 percent of participants taking liraglutide, 55 percent taking naltrexone-bupropion, 49 percent taking lorcaserin, and 44 percent taking orlistat. All active agents were associated with significant excess weight loss compared with placebo at 1 year: phentermine-topiramate, 19.4 lbs.; liraglutide, 11.7 lbs.; naltrexone-bupropion, 11 lbs.; lorcaserin, 7.1 lbs.; and orlistat, 5.7 lbs. Compared with placebo, liraglutide and naltrexone-bupropion were associated with the highest odds of adverse event-related treatment discontinuation.

"Ultimately, given the differences in safety, efficacy, and response to therapy, the ideal approach to weight loss should be highly individualized, identifying appropriate candidates for pharmacotherapy, behavioral interventions, and surgical interventions. Historically, concerns regarding the long-term safety profile of pharmacotherapy for weight loss have limited their clinical use, particularly among medications with significant adrenergic actions or central appetite-suppressing actions. Short-term clinical trials may not provide comprehensive information on the long-term safety of these agents, and prospective postmarketing surveillance studies are warranted," the authors write.


Ressource: Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis, Rohan Khera, MD; Mohammad Hassan Murad, MD, MPH; Apoorva K. Chandar, MBBS, MPH; Parambir S. Dulai, MD; Zhen Wang, PhD; Larry J. Prokop, MLS; Rohit Loomba, MD, MHSc; Michael Camilleri, MD; Siddharth Singh, MD, MS, JAMA, doi:10.1001/jama.2016.7602, published 14 June 2016.

For more latest obesity, nutrition, and weight loss research visit this page: Latest Studies and Research

Related Tags: weight loss pills, weight loss supplements, slimming pills, weight loss drugs, weight loss medication, weight loss pills that work



Get Latest Updates In your Inbox

One Reply so far - Leave your comment

  1. Great thanks for sharing this post. I was looking for something like this. Your blog have inspires me a lot.

    Unlike most diet books, gym memberships, weight loss plans and fat-burner pills on the market,

    The 3 Week Diet comes with my personal, 100% no-nonsense Lose The Weight Or It’s FREE guarantee.

    Find out here: Fast Healthy Weight Loss

    Best rgs

    ReplyDelete